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Cell:117 Fujimori K, Ishikawa M, Otomo A et al (2018) Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

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doi: 10.1053/j.ackd.2020.08.001 62 CondonMBAshbyDPepperRJCookHTLevyJBGriffithMet al

Its structure incorporates two Aib substitutions (positions 2 and 12) that enhance resistance to DPP-4 degradation, along with an amido-linked C-20 di-acid fatty chain at Lys20 that facilitates high-affinity albumin binding, resulting in a half-life of approximately five days 32,34