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Similar content being viewed by others Introduction Dysmetabolism is the abnormal regulation of metabolic processes in the body, leading to imbalances in the way nutrients are processed, and energy is produced or utilized, and is often seen as an intermediary phase of the metabolic health-to-disease continuum

With the use of the ASOs to target the SCN1A NAT, one study was effectively able to rescue the sense SCN1A gene expression, ameliorate neuronal excitability and seizures in a mouse model of DSan effect that almost entirely recapitulates the rescued phenotypes observed via CRISPRa treatment [74, 75]

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