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Case Presentation A 71-year-old female with no prior psychiatric history presented with sudden onset of: Severe anxiety Insomnia Cognitive dysfunction Fatigue Severe neck and shoulder pain Abdominal pain New intolerance to previously well-tolerated foods Symptoms began within months of moving into a new office building , suggesting a potential environmental trigger

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However, based on AR dependency, two distinct metabolic and cellular adaptations contribute to development of resistance to these agents and progression to aggressive and lethal disease, with the tumor ultimately becoming highly glycolytic and with imaging by a tracer of tumor energetics, 18 F-fluorodoxyglucose ( 18 F-FDG)

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