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Semaglutide causes weight loss by targeting three pathways simultaneously: the brain (suppressing appetite and cravings), the stomach (slowing emptying so you feel full longer), and the pancreas (stabilising blood sugar to reduce energy crashes and hunger spikes)

Study #2 (Diabetes, July 2025): In high-fat-fed rats, metformin restored lipid sensing in the upper small intestine, triggering release of the gut hormone GIP

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