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Intranasal administration of Ex-4 at a dose of 0.5 g/kg daily for 7 days before MCAO in mice, rather than intraperitoneal administration at an equivalent dose, exerted neuroprotective effect by reducing infarct volume and neurological deficits which were blocked by knocking down GLP-1 receptor with shRNA (97)

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This is why its so important to understand the effects of this new class of drugs on it. In their review of the available medical literature, the researchers found that GLP-1 drugs improve certain measures of heart function, yet those improvements dont translate into significant improvements in VO 2 max