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If side effects are intolerable at a particular dose level, clinicians may recommend maintaining that dose for an additional 4 weeks before escalating, or reducing to the previous dose temporarily

Treatment typically begins at 2.5 mg weekly for four weeks, serving as an initiation dose rather than a therapeutic dose

J Clin Invest 131(12) [DOI] [PMC free article] [PubMed] Schith HB et al (2012) Brain insulin signaling and Alzheimers disease: current evidence and future directions