A proof-of-concept experiment in transgenic mice (the insulin-resistant db/db mouse model which harbors a mutated leptin receptor) showed that overexpression of OGA, which reduces the level of O -GlcNAcylation, significantly improves whole-body glucose tolerance and insulin sensitivity
Particular attention is needed for potential effects on pancreatic safety, including pancreatitis and pancreatic cancer risk
But beyond helping people feel full, it may also influence how the body responds to food and manages energy
c Injection site reactions include injection siteassociated events of erythema, pruritus, oedema, pain, induration, bruising, reaction, swelling, haemorrhage, hypersensitivity, hematoma, nodule, discoloration, erosion, inflammation, irritation, warmth, atrophy, discomfort, dryness, mass, hypertrophy, rash, scar, abscess and urticaria