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Under hypoxic conditions, the functionality of HIF is primarily mediated by the subunit, where intracellular oxygen concentration affects the protein stability and transcriptional activity of HIF-1 ( Figure 2 2.3 Activation of HIF in hypoxic microenvironment Studies have found that the classical mitogen-activation protein kinase (MAPK), including its regulated extracellular protein kinases (ERK) subfamily, play crucial roles in the hypoxic microenvironment, activating HIF-1, protecting cell development, and avoiding oxidative damage ( + regulatory T cells (Treg)

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Activity of Indatuximab Ravtansine against Triple-Negative Breast Cancer in Preclinical Tumor Models

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