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Expected Return on Innovation Rebounded Since 2022 Analysis shows that the IRR for the top 20 global pharmaceutical companies reached 5.9% in 2024, an increase of 1.6 percentage points from 2023, continuing an upward trend

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In-use stability testing is required for multi-dose nasal sprays to demonstrate that the product remains safe and effective from first use to the last actuation including the microbiological stability of the opened container with repeated sampling