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However, because non-diabetics dont have the same problems with blood sugar regulation as diabetics do, these medications can have side effects, including nausea, vomiting, and diarrhea that can be more severe

Gilbert, M

These mechanistic findings provide a biological foundation for the CV benefits observed in clinical trials and support further exploration of novel incretinbased therapies across cardiometabolic disorders

Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]