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After the introduction of various tricyclics and selective serotonin re-uptake inhibitors (SSRIs), two competing ideas on the action of antidepressants became current, given the observed effectiveness of antidepressants only on chronic use: receptor desensitization and the modulation of second messenger systems (Sanders-Bush et al., 1989)
Cursiefen, C
Schredl M, Weber B, Braus D, et al
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