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The migration of low immunogenic primary melanoma cells into lymph nodes may not be attributed solely to the passive migration of these cells from the primary niche to the metastatic niche, but rather a preferential migration to the lymph nodes to improve tumor fitness and colonization abilities (6365)

it amplifies the melanogenic response to sub-erythemal doses

Amonette and Rosenberg 5 found that the best treatment regimen was topical management with a combination of bed rest, exposure to air, and application of silver nitrate solution, Castellani paint, and gentamicin sulfate cream

That means it's safer for long-term use while still helping reduce swelling, pain, and tissue breakdown