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Methods A selective literature review on GLP1 RAs was conducted, focusing on mechanisms of action, clinical effects, off-label use, esthetic consequences and treatment options

However, ethical considerations, external validity limitations, challenges in double-blinding, and interference from internal and external factors, coupled with inadequate statistical power and significant financial/temporal requirements, have hampered the feasibility of conducting RCTs

Pasupathy S, Tavella R, Grover S, Raman B, Procter NEK, Du YT, et al