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The topline findings from SURPASS-CVOT, disclosed before publication of the main manuscript [11], reported a hazard ratio of 0.92 (95.3% CI 0.831.01) for 3P-MACE in favor of tirzepatide, confirming noninferiority to dulaglutide

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Adding GHK-Cu to a Retatrutide protocol addresses this before it becomes a problem, during the period when the biological conditions for skin remodeling are most active, not after the weight loss has already occurred