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Impaired mitochondrial function in dopaminergic neurons in the substantia nigra can lead to increased oxidative stress, neuronal damage, and neuronal death, contributing to PD progression [20]
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Despite the initial belief that NEOs have low mammalian toxicity, there is growing evidence that NEOs can cause a wide range of toxic effects in animals and humans, including neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive cytotoxicity in vertebrates and invertebrates (Wang et al
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