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Alcoholics who maintain a high fluid intake and high urine flow rate may also experience increased loss of thiamin, exacerbating the effects of low thiamin intake (33)

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Apart from lipid biosynthesis, another critical pro-inflammatory process that NADPH supports in myeloid cells is the production of cytotoxic, diffusive reactive radicals, such as reactive oxygen species (ROS) via NADPH oxidases (NOXes), as well as nitric oxide ( NO) via nitric oxide synthases (NOSes)