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The improvement in reproductive antioxidant defense systems may be due to the increase in reduced glutathione concentration and activities of glutathione peroxidase, catalase, and SOD enzymes (28, 61, 62), which protect the reproductive organs' defense systems against ROS attacks

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Inflammation is known to promote pigmentation such as in smokers melanosis and chronic oral inflammation from disease states

Yet, more recently, a metabolomic analysis reveals the importance of glutamine uptake by ASCT2 and its conversion into ROS-producing intermediate metabolite -Ketoglutarate as marker of sensitivity during sulfasalazine xCT-inhibition cell death in head and neck squamous cells carcinoma (46)