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Microbiome overgrowth can result from changes in gut motility (eg: irritable bowel syndrome (IBS), narcotic use and diabetes mellitus), anatomical disorders (eg: small intestinal diverticulosis and blind intestinal loops), decreased stomach acid production (due to the use of proton pump inhibitors) and immune disorders (eg: HIV) (7,8)

Given that Glu is primarily neuroactive while Gln is storable and neuroinactive, the Gln/Glu ratio can reflect the efficiency of Glu uptake by astrocytes and its conversion to Gln, which is crucial for regulating excitatory neurotransmission [20]

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