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Animal offspring exposed to spironolactone during late pregnancy exhibited changes in the reproductive tract, including dose-dependent decreases in weights of the ventral prostate and seminal vesicle in males, ovaries and uteri that were enlarged in females, and other indications of endocrine dysfunction that persisted into adulthood

Unfortunately, the immunohistochemistry protocol and the antibody used in the mentioned study did not appear to have the necessary specificity for GLP1R immunohistochemistry in human tissues

This provides format options for individuals who prefer non-injection alternatives, though providers determine clinical appropriateness based on individual patient factors

Dosage in Adult and Pediatric Patients 12 Years and Older The recommended dosage of DUPIXENT for adult and pediatric patients 12 years of age and older is specified in Table 3