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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

More studies are needed to determine how common and significant the changes are

Randomized and controlled studies indicate beneficial effects on depressive symptoms, sleep quality, cognitive function, and neurobiological markers when Ginkgo biloba is combined with conventional antidepressants or cardiovascular therapies

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