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just taking a sample of convenience and its unclear how participants were blinded to patch use in one case), were not registered on Clinicaltrials.gov, and were not published in what I consider rigorous journals that are listed on PubMed

None of these studies have been able to establish causality, and complicated T2D and hypertension are known risk factors for NAION (93)

(The mean age in Horneffs study was 59.8 years, with half being older than 61.) While there may be a signal that we need to pay more attention to bone [health], I dont think this should dissuade people, necessarily, from considering these treatments, Yu said.

The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies