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Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

Badenhorst T, et al

Aldose Reductase Inhibitors Aldose reductase inhibitors (ARI) work by blocking the enzyme aldose reductase in the polyol pathway, which under hyperglycemic conditions converts excess glucose into sorbitol, a sugar alcohol that accumulates in nerves and causes osmotic stress, oxidative damage and impaired nerve function [116]