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48 A recent study demonstrated that NADPH oxidase activation and the production of ROS through lipid raft clustering is an important molecular mechanism that triggers homocysteine-mediated oxidative injury of podocytes

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Interestingly, cell culture models have shown that ALS is associated with reduced glutathione levels due to mitochondrial dysfunction, and that reduced glutathione levels can result in elevated levels of glutamate (DAlessandro 2011)