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The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

Stopping semaglutide abruptly is not recommended, and tapering under medical supervision helps manage risks

Individuals with Gut Absorption Issues : Conditions like Crohn's disease, celiac disease, or pernicious anemia (an autoimmune condition where the body can't produce intrinsic factor, a protein needed for B12 absorption) can significantly impair B12 uptake

10.1016/j.cell.2008.07.002 Cell 59 NakahataY.SaharS.AstaritaG.KaluzovaM.Sassone-CorsiP