Discussion DKD is one of the fastest-growing causes of chronic kidney disease, with about 40% of diabetic patients progressing to DKD
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Given our observations of transcriptional, functional, and metabolic immaturity in SC-islets, we profiled mitochondrial mass and structure of SC-islets at different stages of differentiation and human islets to obtain insights into limitations in mitochondrial respiration as recent studies have had discordant results regarding reductions in mitochondrial mass in SC-islets compared to primary human islets 5,10