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doi:10.1097/ede.0000000000000804

CBRs may attenuate pro-inflammatory cytokine secretion by interfering with the phosphorylation of mitogen activated protein kinases (MAPK), such as extracellular signal-regulated kinase (ERK), which is known to participate in pro-inflammatory pathways, as shown in microglial cell line cultures (Eljaschewitsch et al., 2006

115,125,126 NADPH as the final reducing power for antioxidant defense Besides functioning as the electron donor for ROS production, NADPH also supplies the reducing power for antioxidant defense

Subsequently, M2 phenotype is polarized from macrophages and primarily responsible for tissue repair and anti-inflammatory pathways via producing mediators such as IL-10 and TGF- [29]