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The inhibition of somatostatin by DSIP has been found by a separate study, thus leading to the speculation that this peptide might have larger and more universal functions regarding human physiology than just primary sleep promotion, for which the direct inhibitory effects of somatostatin are more than peculiar

Alternative explanations (direct GLP-1 receptor effects on nerves, nutrient deficiency neuropathy, mechanical nerve compression, inflammatory processes) remain valid

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