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Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

Retatrutide is a triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors

A systematic review of the safety of tirzepatide-a new dual GLP1 and GIP agonist is its safety profile acceptable