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The following are documented in published clinical data and are not edge cases

doi: 10.3389/fnagi.2026.1689139 Received 20 August 2025 Revised 19 December 2025 Accepted 15 January 2026 Published 04 February 2026 Volume 18 - 2026 Edited by Pei Shang, Mayo Clinic, United States Reviewed by Maria Bayliak, Vasyl Stefanyk Precarpathian National University, Ukraine Johannes Riegler, Calico Life Sciences LLC, United States Updates Copyright 2026 Jamerson, Bradshaw and Bradshaw

Human safety data is limited, so its full risk profile is not established

Together, these results support the possibility that peripheral immune-metabolic alterations are linked to neurodevelopmental pathways implicated in ASD, consistent with emerging evidence that immune signaling can influence brain development