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Blood pressure recordings were performed by the Telemetry Unit for Cardiovascular Phenotyping at the University of Copenhagen, supported by the Novo Nordisk Foundation (grant number NNF18OC0032728 to M.B.T.)

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To control the FDR in each comparison, we applied the standard Benjamini-Hochberg method to obtain an adjusted p-value for each sgRNA (Supplementary Data 2)