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As these receptors are activated by the medication, your brain's arousal systems may temporarily downregulate, especially if appetite suppression leads to overall reduced caloric intake during the adjustment phase

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As of August 2023, Mississippis Board of Medical Licensure banned off-label prescribing of GLP-1 agonists solely for weight loss

Brunner emphasized that compounded drugs are typically not covered by insurance because of their lack of FDA approval, and therefore oftentimes more expensive than FDA approved medications