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Compared with full basal-bolus insulin regimens, the combination of GLP-1 agonist plus insulin resulted in a marginal 0.1% reduction in HbA1c, a 33% lower risk of hypoglycaemia and a mean 5.66-kg reduction in weight

In contrast, the passive membrane permeation of small molecules and macrocyclic peptides is reasonably well developed and understood, to the point where computational models are now able to predict the permeability of small molecule drugs 6,7 and macrocyclic peptides with predominantly hydrophobic side chains 8 , especially when coupled with continuous constant p H molecular dynamics (C p HMD) models for small molecule drugs 6 (Fig

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