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These CPPs can be fusogenic lipids for endosomal escape, novel CPPs for sophisticated and targeted delivery to specific organs and organelles, and CPPs linked to specific ligands such as transferrin, folic acid, specific antibodies, and RGD peptides that increase target specificity (Xie et al., 2020)

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330,331 It is believed that IR and obesity play prevalent roles in causing PCOS, and PCOS women show an higher increased comorbidities of IR, including obesity, dyslipidemia, hypertension, and T2DM than healthy women