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The mice were fasted for 20 h and then intraperitoneally injected with 8 g/kg CCK-8 as previously described

A superimposition of our structure with the crystal structure (PDB ID: 2UZX) suggests that, upon the tethering of the N-terminal segment to the PSI and IPT1 domain of c-MET, the entire stalk region of c-MET rotates outward by ~20 (the pivot point is located at the linker between PSI and IPT1 domains), resulting in a more extended conformation (Supplementary Fig

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Tirzepatide (Zepbound, Mounjaro) is the most effective weight loss medication, producing 15-22% average body weight loss in clinical trialssignificantly better than all other FDA-approved options