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Iron chelators such as deferoxamine and deferiprone, while effective in mitigating epithelial ferroptotic injury in preclinical models, carry the risk of systemic iron depletion and may exacerbate anemia-a condition already prevalent among IPF patients due to chronic inflammation and reduced erythropoiesis (178)
The ability to neutralize these oxidants is essential to maintain pulmonary health
Figure 2 4.4 Metabolic crosstalk between hepatocellular carcinoma cells and tumor infiltrating lymphocytes The metabolic reprogramming of T cells occurs during their self-activation process, transitioning rapidly from the characteristic metabolism of Tn cells, oxidative phosphorylation (OXPHOS), and fatty acid oxidation (FAO), to the characteristic metabolic processes of Teff cells, glycolysis and glutamine decomposition, in order to sustain growth and proliferation (159)
J Am Chem Soc 2023, 145 (17), 98349839
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