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See Renard et al

Zepbound mimics the action of two natural hormonesGLP-1 and GIPthat play a key role in controlling hunger, insulin secretion, and the overall metabolism of food

If a patient has two attacks of gout within the same 12 months, it is generally recommended that they be treated with a medication to lower the uric acid, which colchicine does not accomplish

Monitoring approach: Establish clear metrics (visual field, OCT, visual acuity), measure every 3-6 months, continue peptides if stable or improving, consider break if stable 12+ months on treatment, resume immediately if decline detected during break, accept ongoing use if clearly beneficial and well-tolerated