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A randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disorders

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The mechanisms underlying AHR can be broadly categorized as follows: (1) hypertrophy of airway smooth muscle cells and increased contractility [46], (2) loss of the maximal plateau of contraction observed in normal bronchi upon inhalation of bronchoconstrictive agents due to airway inflammation [47], (3) thickening of the airway wall due to edema and structural remodeling, leading to airway smooth muscle contraction [48], and (4) sensitization of sensory nerves by inflammatory processes [49]