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Management of antipsychotic-induced hyperprolactinaemia

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Benefits & Considerations Potential Benefits: Greater weight loss efficacy than single-agent GLP-1s Enhanced satiety and appetite control Reduced caloric intake without stimulant side effects Possible benefits on glucose regulation and lipids Considerations: Still experimental not yet available for clinical use May share similar GI side effects (nausea, fullness, constipation) Requires ongoing injection therapy for maintenance The Future of Multi-Hormone Obesity Therapy If current trials continue to show success, cagrilintide-based combinations could usher in a new generation of multi-agonist weight-loss medicationssimilar to how tirzepatide built on semaglutides success by adding GIP activity

P62 strictly controls NRF2 and can inhibit ferroptosis