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In production settings, immunocompromised cattle are highly susceptible to URT dysbiosis, which often leads to bovine respiratory disease (BRD) 98 , characterized by the overgrowth of opportunistic bacteria, including Pasteurella multocida , Histophilus somni , Mannheimia haemolytica , and Mycoplasma bovis , frequently in co-infection with respiratory viruses such as Bovine respiratory syncytial virus (BRSV), Bovine viral diarrhea virus (BVDV), and Bovine parainfluenza virus type 3 (BPIV-3) (Table 2)

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