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While overall we found a decreasing pattern of urinary and salivary cortisol levels throughout the control day, we showed individual differences in the amount of cortisol but also in the fluctuations of the cortisol patterns
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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]
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