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Short-term synaptic plasticity

Inspection report (Form FDA 483) sent October 10, 2024FDA Warning: Drug products failed to meet the requirements of approved outsourcing facilities under Section 503B of the Federal Food, Drug, and Cosmetic Act (FD&C Act)

If an abnormally high cumulative doses are administered, or the patient has low plasma pseudocholinesterase activity, then Phase I block can progress into Phase II block due to the inclusion of additional mechanisms that come into play when high synaptic levels of succinylcholine are achieved

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