doi: 10.3389/fanim.2025.1713884 Received 23 October 2025 Revised 25 November 2025 Accepted 28 November 2025 Published 17 December 2025 Volume 6 - 2025 Edited by Wellison J
et al., 2022), red ginseng polysaccharide (Zhai et al., 2022) Dihydroisotanshinone I (Wu et al., 2021).inhibits the proliferation, colony formation and induces ferroptosis of lung cancer cells by the interfering mRNA and/or protein expression and/or degradation of SLC7A11 or GPX4
Current knowledge only partially explains how distinct TAM subsets, such as inflammatory M1-like macrophages, immunosuppressive M2-like macrophages, lipid-associated TAMs, and embryonically derived tissue-resident macrophages, differ in their ability to induce or restrain ferroptosis within tumors
Increased adsorption improves the delivery of glutathione to macrophages which are involved in the immune decision regulating two sides of the immune response known as TH1 and TH2