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demonstrated that a chitosan-based mucoadhesive microemulsion offered superior brain-targeting capabilities compared with polymeric nanoparticles due to enhanced diffusion through the nasal mucosa, resulting in higher brain concentrations and greater intranasal bioavailability, making it a promising non-invasive technique for treating brain disorders (Shah et al., 2021)

The study compared two groups of women where one group received 600 mg NAC and 500 mcg folic acid daily, and the other group only received NAC