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As mast cells are implicated in brain injury, stress, and PTSD, activation of mast cells in these conditions could increase neuroinflammation and thereby accelerate the onset and progression of AD

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The role of lipopolysaccharide-induced cell signalling in chronic inflammation

The study found that this pathway begins with the activation of c-Jun-N-terminal kinase 1 (JNK1) and increased receptor-interacting protein 1 levels (RIP-1)