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IL-21 activates STAT3 and STAT1 to promote Th17 cell differentiation, and activates STAT3 and RORt to inhibit Foxp3 mRNA expression [35]

Symptom Monitoring: Even though serious adverse events did not occur in trials, individual monitoring for headache, gastrointestinal symptoms, or unusual effects allows for early detection of tolerability issues and appropriate management adjustments

Additionally, electroencephalography studies involving individuals with ASD have demonstrated atypical gamma oscillations, and magnetic resonance imaging (MRI) studies have revealed atypical local connectivity, both indicative of a dysregulated E/I balance [3, 16, 17]

Plant Soil 219(12):2128 Ma X, Geiser-Lee J, Deng Y, Kolmakov A (2010) Interactions between engineered nanoparticles (ENPs) and plants: phytotoxicity, uptake and accumulation