Enhanced growth hormone sensitivity in damaged tissue accelerates proliferative responses necessary for replacing lost cells
They were discovered through a population of people born with a genetic mutation that gave them an 88% lifetime reduction in cardiovascular disease risk
230:639-648 (2009) Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S
References Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Wei M, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans