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doi: 10.1016/j.trsl.2012.06.001 119 XuHHeYYangXLiangLZhanZYeYet al

The virus induces functional exhaustion of specific CD8 + T cells through high antigen load and upregulates inhibitory receptors such as PD-1, thereby preventing the immune system from effectively clearing the virus [175, 176]

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Comparative Pharmacokinetics of Three Triterpene Acids in Rat Plasma after Oral Administration of Poria Extract and its Formulated Herbal Preparation: GuiZhi-FuLing Capsule