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Human study groups were generally very small

Others are used off-label and have strong clinical evidence supporting their use for weight loss

A population-based study of 467 matched pairs of GLP-1 users and non-users with type 2 diabetes and liver cirrhosis found GLP-1 use associated with lower risks of death, cardiovascular events, decompensated cirrhosis, hepatic encephalopathy, and liver failure

GLP-1 RA users who underwent upper endoscopy and combined upper and lower endoscopy had an increased risk for aspiration pneumonia (hazard ratios, 1.82 and 2.26, respectively), but the risk was not increased for those undergoing lower endoscopy