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Practical timing considerations include ensuring patients can commit to weekly injections and follow-up appointments, verifying insurance coverage or discussing out-of-pocket costs before initiation, scheduling initiation when patients can manage potential gastrointestinal side effects (avoiding major life events, travel, or work commitments in the first 4-8 weeks), and confirming patients are not planning pregnancy in the near term

Can I split a tirzepatide dose into two injections per week

A Mayo Clinic study revealed that this dual treatment led to significantly greater weight loss than tirzepatide alone

Stopping GLP-1 therapy typically results in reversal of therapeutic effects, including deterioration in blood glucose control and weight regain within weeks to months