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Active anticoagulation with a factor Xa-inhibitor (apixaban, rivaroxaban or edoxaban) was defined as a plasma concentration 30ng/mL

The prevalence per million individuals in the United States and incidence per million live births are 0.36 and 0.57 for RDEB-sev gen, 0.14 and 0.30 for RDEB-O, and 1.49 and 2.12 for DDEB, respectively.[140] The clinical manifestations demonstrate a continuum of severity that complicates definitive diagnosis, especially early in life

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